Syrup Presentation

Each liquid contains:
Dextromethorphan HBR IP 10 mg
Chlorpheniramine Maleate IP 2 mg
Phenylephrine HCL 5 mg

This combination is used together to treat allergic symptoms or congestion.

Uses

• Running nose
• Sneezing
• Watery eyes
• Skin rashes
• Hives
• Cough caused by some allergies

About Composition

Dextromethorphan hydrobromide:

Dextromethorphan suppresses medullary cough centre and is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate). It acts as a non- competitive channel blocker and is one of the widely used antitussives Dextromethorphan is categorized as an opioid drug that acts as antagonist to the NMDA glutamatergic receptor.

Phenylephrine HCL:

Phenylephrine is sympathomimetic drug and mimics the actions of epinephrine (commonly known as adrenaline) or norepinephrine. Phenylephrine selectively binds to alpha-1 receptors which leads to blood vessels to constrict leads to nasal decongestant action.

Chlorpheniramine Maleate:

Diphenhydramine acts on histamine H1 receptor as an inverse agonist. It structurally resembles the ethanolamine class of antihistaminergic agents. By antagonising the effects of histamine on the capillaries, it can reduce the tenseness of allergic symptoms. It also acts centrally as it crosses the blood–brain barrier and inversely agonizes the H 1 receptors which can result in drowsiness.

Side Effects

• Severe anxiety
• Tremors
• Headache
• Weakness
• Painful urination
• Dizziness
• Nausea
• Vomiting
• Nervousness

Contraindication

• Contraindicated in high blood pressure
• Contraindicated in glaucoma
• Contraindicated in enlarged prostate

Pregnancy: Ask your physician before use

Drug Interactions

Alcohol